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Although the precise cellular mechanism remains to be fully elucidated, the C3b-opsonized synapses are likely phagocytosed by resident microglia, the primary phagocytic cells in the brain that express C3 receptors (CR3)

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If methylfolate causes side effects (restlessness, irritability, feeling wired): reduce dose, try niacin (50–100 mg) every 30 minutes until side effects cease, switch to folinic acid, or switch methylcobalamin to hydroxocobalamin.³³† You do not need genetic testing